Bredereck噁唑合成法(Bredereck Oxazole Synthesis) | 化学空间...

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2014年12月22日噁唑也是一个弱碱,其共轭酸的pKa值是0.8,相比而言,咪唑的共轭酸的pKa是7。 基本文献 H. Bredereck, Bangert, R. Angew. Chem. Int. Ed. 1962, 1, 662...概要α-卤代酮与甲酰胺（或脲）合成噁唑的手法。用硫代酰胺代替甲酰胺，可以得到噻唑类产物。噁唑是一个芳香性化合物，但是其芳香性不及噻唑。噁唑也是一个弱碱，其共轭酸的pKa值是0.8，相比而言，咪唑的共轭酸的pKa是7。Bredereck噁唑合成法(Bredereck Oxazole Synthesis)